Following a successful start to his racing career in France, Cluzel made his World Championship debut as a wildcard in the French 125cc Grand Prix in 2005, before making his full time debut in the 250cc World Championship the following season. The Frenchman spent two seasons in the Moto2 World Championship, where he claimed a race win and a podium finish before switching to the WorldSBK paddock.
Cluzel has been a regular contender in WorldSSP since making his debut in the class back in 2012. The 30-year-old Frenchman has amassed 17 wins 40 podium finishes and has ended as runner up in the championship on three occasions.
2019 was a strong year for Cluzel, where he took three podiums and three victories to finish the season third in the rider standings.
In 2020, Cluzel stayed with the GMT94 Yamaha WorldSSP Supported Team alongside Corentin Perolari. The Frenchman was eventual champion Andrea Locatelli's closest rival throughout the season, taking six second-place finished in the first seven races. An incident in the final race at Aragon saw him pick up a major leg injury, and although he returned to racing for the final two rounds, he was still not fully recovered.
Despite this, Cluzel finished fourth in the standings and will return to the GMT94 Yamaha squad for 2021, this time alongside Federico Caricasulo, with hopes of finally taking that elusive championship victory.